Please post all VU+ Duo2 LCD4Linux support questions in this section

[Kojo_]

Nothing on it. No clock, no weather, no calendar, nothing. I can make changes via the webIF and they transfer but nothing I do there makes any difference.

What if you disable every option you have selected in your screenshot (those that are in green) and start with simple option that should always work, like the clock. Once you have that figured out, then move to the next one.
BTW, I have the exact same options in my picon -settings, so double check channel reference.